Philippe Séguéla

This study shows that inducing hyperexcitation in neonatal mice leads to long-term social behavior deficits and increased interneuron density, linking E/I imbalance to ASD-like symptoms.

This study investigates ependymal cilia dysfunction in multiple sclerosis, finding dysregulated ciliary genes and impaired ciliary function in MS patients and animal models.

This study shows that gut microbiota from fibromyalgia patients causes pain in mice, and transferring healthy microbiota alleviates symptoms in humans.

This study shows acetylcholine and netrin-1 work together to enable persistent firing in the entorhinal cortex, essential for spatial working memory.

This study shows chronic lithium treatment reduces neuronal excitability and shifts the excitatory/inhibitory balance toward inhibition in mouse cortical neurons.

This study shows that reduced dopaminergic inhibition in the anterior cingulate cortex contributes to neuropathic pain by increasing neuronal excitability.

This study identifies distinct pre- and post-synaptic roles of DCC in hippocampal synaptic plasticity and spatial memory in adult mice.

This study identifies netrin-1 as an activity-dependent effector of synaptic plasticity by promoting GluA1-containing AMPAR insertion at hippocampal synapses.