Author

Hidde S. Offerhaus

Delft University of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Ieva JaskovikaitėiD· 2 shared Martin DepkeniD· 2 shared Stephen K. JonesiD· 2 shared Marius VinogradovasiD· 1 shared Uršulė BarkauskaitėiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersBiochemistry

Ieva JaskovikaitėORCID

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2 papers

Recent·Most cited

Supercoiling twists Cas9 off-target discrimination when nicking and cleaving

Ieva Jaskovikaitė, Hidde S. Offerhaus, Marius Vinogradovas, Uršulė Barkauskaitė, Martin Depken, Stephen K. Jones

This study investigates how DNA supercoiling affects Cas9 off-target cleavage by mapping cleavage rates and sites across different topologies using NucleaSeq and a biophysical model.

bioRxiv · Apr 1, 2026 · PreprintBiochemistry

A mechanistic free-energy model explains and predicts sequence- and context-dependent CRISPR-Cas9 activity

Hidde S. Offerhaus, Ieva Jaskovikaitė, Stephen K. Jones, Martin Depken

The paper introduces CRISPRzip, a mechanistic model that predicts CRISPR-Cas9 activity based on sequence and context, validated by experimental data.

bioRxiv · Jan 5, 2026 · PreprintBiophysics