Author

Uršulė Barkauskaitė

Vilnius UniversityORCID 0009-0002-3182-2317Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Hidde S. Offerhaus· 1 shared Ieva JaskovikaitėiD· 1 shared Marius VinogradovasiD· 1 shared Martin DepkeniD· 1 shared Stephen K. JonesiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

Hidde S. Offerhaus

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintApr 1, 2026

Supercoiling twists Cas9 off-target discrimination when nicking and cleaving

Ieva Jaskovikaitė, Hidde S. Offerhaus, Marius Vinogradovas…·Stephen K. Jones

This study investigates how DNA supercoiling affects Cas9 off-target cleavage by mapping cleavage rates and sites across different topologies using NucleaSeq and a biophysical model.

DOI 10.64898/2026.04.01.715559

DNA methylationexperimental assay

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