Author

Ieva Jaskovikaitė

Vilnius UniversityORCID 0009-0005-0726-4847Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:DNA methylation· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Hidde S. Offerhaus· 2 shared Martin DepkeniD· 2 shared Stephen K. JonesiD· 2 shared Marius VinogradovasiD· 1 shared Uršulė BarkauskaitėiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Hidde S. Offerhaus

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiochemistrybioRxivPreprintApr 1, 2026

Supercoiling twists Cas9 off-target discrimination when nicking and cleaving

Ieva Jaskovikaitė, Hidde S. Offerhaus, Marius Vinogradovas…·Stephen K. Jones

This study investigates how DNA supercoiling affects Cas9 off-target cleavage by mapping cleavage rates and sites across different topologies using NucleaSeq and a biophysical model.

DOI 10.64898/2026.04.01.715559

DNA methylationexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivPreprintJan 5, 2026

A mechanistic free-energy model explains and predicts sequence- and context-dependent CRISPR-Cas9 activity

Hidde S. Offerhaus, Ieva Jaskovikaitė, Stephen K. Jones, Martin Depken

The paper introduces CRISPRzip, a mechanistic model that predicts CRISPR-Cas9 activity based on sequence and context, validated by experimental data.

1 citation

DNA methylationproteomics

𝕏 PostBluesky