Inhibition of the gut ceramidase Asah2 decelerates the vertebrate ageing rate
Ayami Takaochi, Kota Abe, Yuki Sugiura, Akane Kawaguchi, Shigehiro Kuraku, Hide-Nori Tanaka, Daisuke Motooka, Kaori Tanaka, Farzana Ferdousi, Masao Nagasaki, Yasuyuki Ohkawa, Tohru Ishitani
This study shows that reducing gut ceramidase Asah2 activity slows ageing in vertebrates by altering ceramide levels and microbiota composition.
bioRxiv · May 4, 2026 · PreprintDevelopmental Biology