Yuki Sugiura

Biosensor-enabled single-molecule enzyme activity profiling for function-based molecular counting

This paper introduces a biosensor-based method for single-molecule enzyme activity profiling without enzyme-specific substrates, enabling absolute quantification of active enzyme molecules in cellular and circulating samples.

Oxidized phosphatidylinositol impairs lysosomal membrane repair to promote ferroptosis

The paper identifies oxidized phospholipids that impair lysosomal membrane repair and promote ferroptosis across multiple cell types and conditions.

Maternal progesterone signaling establishes lifelong oral homeostasis

This study identifies maternal progesterone signaling through mPRδ as critical for establishing lifelong oral homeostasis via a hormone-lipid-microbiome axis.

Inhibition of the gut ceramidase Asah2 decelerates the vertebrate ageing rate

This study shows that reducing gut ceramidase Asah2 activity slows ageing in vertebrates by altering ceramide levels and microbiota composition.

Cell-autonomous thermogenesis of macrophage alters its antibacterial function

This study shows that macrophages generate heat through a cell-autonomous mechanism, which reduces their antibacterial function in cold environments.

Microbiome-host interactions drive a trade-off between sleep quality and lifespan in Drosophila

This study shows that microbiome-host interactions in Drosophila create a trade-off between sleep quality and lifespan through specific bacterial metabolites and host responses.

Cholesterol sulfate prevents maternal-fetal conflict by locally modulating immune reactivity

This study shows that cholesterol sulfate prevents maternal-fetal immune conflict by modulating immune reactivity in pregnant mice and humans.

Cysteine depletion triggers adipose tissue thermogenesis and weight-loss.

This study shows that cysteine depletion induces adipose browning and weight loss in mice, mediated by noradrenaline signaling via β3-adrenergic receptors, without requiring UCP1.

Integrated hepatic ferroptosis gene signature dictates pathogenic features of ferroptosis

The paper establishes a murine model of iron overload-induced hepatic ferroptosis and identifies a gene signature that predicts ferroptosis-related liver damage in both mice and humans.

Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.

This study shows that elevated taurine reduces age-related inflammation by inhibiting the NLRP3 inflammasome and pyroptosis in mice.

Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state

This study shows that maternal progesterone and adipose mPRε regulate the embryonic nutritional state by affecting glucose provision and metabolic outcomes in offspring.

Distinct classes of antidepressants commonly act to shape pallidal structure and function in mice

The paper shows that different antidepressants induce similar structural and molecular changes in the pallidum of mice, suggesting a common mechanism in their antidepressant effects.

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies

This study shows that inhibiting IDO1 restores hippocampal glucose metabolism and rescues cognition in Alzheimer's disease models.

Postnatal xanthine metabolism regulates cardiac regeneration in mammals

This study shows that postnatal xanthine metabolism regulates cardiac regeneration by linking redox state to cardiomyocyte proliferation and regenerative potential in mice.

Hypothalamic prostaglandins facilitate recovery from hypoglycemia but exacerbate recurrent hypoglycemia in mice

This study investigates the role of hypothalamic prostaglandins in glucose recovery during acute hypoglycemia and recurrent hypoglycemia in mice, finding that they enhance recovery but impair counter-regulatory responses during recurrence.

Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia

This study shows that loss of SPNS1 in the nervous system causes dysmyelination and white matter dysplasia in mice, suggesting a role for SPNS1 mutations in human congenital white matter disorders.

Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia

This paper identifies shared GABA transmission pathology in L-DOPA-induced and tardive dyskinesia models through structural and functional analysis of striatal neurons.

Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild

This study identifies key yeast and bacterial species affecting Drosophila larval growth and shows their functional roles in gene regulation and metabolism.

Identification of PTBP1 responsible for caspase dependent YRNA cleavage

The paper identifies PTBP1 as responsible for caspase-dependent YRNA cleavage during apoptosis, revealing its role in ASR biogenesis.