Daisuke Motooka

Leptin receptor deficiency suppresses gastric tumorigenesis by limiting stromal activation and tumor microenvironment development.

Purification-free cryo-EM reveals endogenous assemblies from minute tardigrade samples

This study uses purification-free cryo-EM to analyze endogenous macromolecular assemblies from tardigrade samples, revealing structures like vitellogenin and ferritin.

Real-time near-infrared imaging distinguishes nasopharyngeal colonization from aspiration of Streptococcus pneumoniae and identifies aspiration as a trigger of severe disease

This study uses real-time near-infrared imaging to distinguish nasopharyngeal colonization from aspiration of Streptococcus pneumoniae and shows aspiration triggers severe disease.

Core genome MLST reveals genetic and BafA-associated phenotypic diversities in Bartonella henselae strains

The paper develops a core genome MLST scheme for Bartonella henselae, revealing higher genetic resolution and associations between bafA subtypes and phenotypic differences in endothelial cell interactions.

Infant acquisition of Stickland-metabolizing bacteria prevents Clostridium botulinum infection

The paper shows that infant acquisition of Stickland-metabolizing bacteria prevents Clostridium botulinum infection by competing for amino acids.

Retinoid signaling promotes frontonasal identity while repressing maxillary identity during craniofacial development

This study shows retinoid signaling specifies frontonasal identity and represses maxillary identity in cranial neural crest cells during facial development in mice.

Shaving black fur uncovers hidden issues in p16-3MR mice

The paper identifies issues with the p16-3MR mouse model for in vivo bioluminescence imaging, showing that fur shaving is necessary for accurate signal detection and that previous results may be unreliable.

Inhibition of the gut ceramidase Asah2 decelerates the vertebrate ageing rate

This study shows that reducing gut ceramidase Asah2 activity slows ageing in vertebrates by altering ceramide levels and microbiota composition.

Nutrient Acquisition Drives Edwardsiella tarda Pathogenesis in Necrotizing Soft Tissue Infection

This study identifies nutrient acquisition genes critical for Edwardsiella tarda survival in NSTI using TraDIS, showing metabolic adaptation drives pathogenesis.

A cattle-derived human H5N1 isolate suppresses innate immunity despite efficient replication in human respiratory organoids

This study uses human respiratory organoids to show that a cattle-derived H5N1 isolate replicates efficiently but suppresses innate immune responses, explaining its mild clinical presentation in humans.

Identifying Genetic Variations in emm89 Streptococcus pyogenes Linked to Severe Invasive Infections

The paper identifies genetic variations in emm89 Streptococcus pyogenes associated with invasive infections using genome-wide association studies and validates one mutation's effect on bacterial growth.

Oral antigen exposure under co-stimulation blockade generates Treg cells to establish immune tolerance despite prior sensitization

This study shows that oral antigen exposure with co-stimulation blockade generates stable regulatory T cells in antigen-sensitized mice, establishing long-term immune tolerance.

Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis thymoma

This study uses spatial transcriptomics to identify medullary niche features in thymoma and thymic hyperplasia associated with myasthenia gravis pathogenesis.

Age-associated aberrations of cumulus-oocyte interaction and microfilamentous structure in the zona pellucida decline female fertility

This study shows that age-related structural changes in the zona pellucida reduce fertilization rates in mice by impairing cumulus-oocyte interactions and sperm binding.

The cell wall polymer initiates plasma membrane partitioning in mycobacteria

The paper shows that the cell wall polymer, not active polymerization, is critical for membrane partitioning in Mycobacterium smegmatis.

Advancing single cell technology: iSCseq drives living subcellular transcriptomic profiling in osteoimmune diversity

The paper introduces iSCseq, a method that captures subcellular transcriptomic changes in living cells, revealing new osteoclast subsets and subcellular connections.