Masao Nagasaki

Inhibition of the gut ceramidase Asah2 decelerates the vertebrate ageing rate

This study shows that reducing gut ceramidase Asah2 activity slows ageing in vertebrates by altering ceramide levels and microbiota composition.

Comprehensive genomic atlas of plasma proteome in the Japanese population: the Nagahama study

The paper identifies population-specific pQTLs and drug targets in the Japanese population by integrating plasma proteome and genome data.

Phased genome assemblies and pangenome graphs of human populations of Japan and Saudi Arabia

The paper constructs a pangenome graph reference for Japanese and Saudi Arabian populations, showing improved variant detection compared to linear references and comparable performance to existing pangenome graphs.

MEGA-FISH: Multi-omics Extensible GPU-Accelerated FISH Processing Framework for Huge-Scale Spatial Omics

MEGA-FISH is a GPU-accelerated framework for spatial omics image analysis that improves processing speed and accuracy for large-scale tissue data.

3.5KJPNv2, An allele frequency panel of 3,552 Japanese Individuals

The paper constructs a population-level allele frequency panel of 3,552 Japanese individuals using a standardized pipeline and makes it publicly available.