Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions
Qin Huang, Albert Tian Chen, Ken Y. Chan, Hikari Sorensen, Andrew J. Barry, Bahar Azari, Thomas Beddow, Qingxia Zheng, Binhui Zhao, Isabelle G. Tobey, Fatma-Elzahraa Eid, Yujia A. Chan, Benjamin E. Deverman
This paper identifies AAV capsids that target specific proteins on the blood-brain barrier, enhancing CNS tropism and enabling predictable gene delivery vectors.
bioRxiv · Oct 31, 2022 · PreprintSynthetic Biology