Andrew J. Barry

Data-driven consideration of genetic disorders for global genomic newborn screening programs

The paper develops a machine learning model to prioritize genes for newborn sequencing programs based on factors like evidence of disease natural history and treatment efficacy.

An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery

The paper develops a modified AAV capsid that targets the human Transferrin Receptor to enhance gene delivery to the CNS, showing improved reporter expression and therapeutic potential for Gaucher disease.

Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions

This paper identifies AAV capsids that target specific proteins on the blood-brain barrier, enhancing CNS tropism and enabling predictable gene delivery vectors.