Isabelle G. Tobey

This study shows HPV infection increases cGAMP but reduces STING and IRF3 activation, dampening antiviral responses while increasing epithelial proliferation genes.

This study identifies PRMT1 as a critical factor in HPV18 infection by modulating alternative splicing and mRNA stability, promoting persistent infection in primary human cervical cells.

The paper develops a modified AAV capsid that targets the human Transferrin Receptor to enhance gene delivery to the CNS, showing improved reporter expression and therapeutic potential for Gaucher disease.

The paper introduces Fit4Function, a machine learning approach to engineer AAV capsids with multiple traits, achieving high transduction efficiency and cross-species prediction.

This paper identifies AAV capsids that target specific proteins on the blood-brain barrier, enhancing CNS tropism and enabling predictable gene delivery vectors.

The paper identifies LY6A as a novel receptor for AAV-PHP.B vectors, enabling efficient gene delivery across the blood-brain barrier in mice.