Binhui Zhao

The paper introduces Synapse-seq, a method to link transcriptomes to synaptic architecture by using protein-guided RNA barcoding, revealing new insights into neural connectivity and cell type-specific dendritic structures.

This study identifies Nptx2 as a regulator of complement activity in the brain, showing its role in preventing microglial synapse elimination in health and disease.

The paper introduces Fit4Function, a machine learning approach to engineer AAV capsids with multiple traits, achieving high transduction efficiency and cross-species prediction.

This paper identifies AAV capsids that target specific proteins on the blood-brain barrier, enhancing CNS tropism and enabling predictable gene delivery vectors.