Integrin-TGFb axis induces partial EMT in basal-like cells to lead collective invasion
Abdelrahman G. El-Gammal, Lisa Jansen, Mathijs P. Verhagen, Hilverd Kremer, Sarmad Soufi, Mina Masoudnia, Isabella da Silva, Denise Westland, Peter Bult, Riccardo Fodde, Monique M. A. Verstegen, Martijn Gloerich, Saskia W. C. van Mil, Antoine A Khalil
The paper identifies the Itg2-TGFβ axis as a regulator of partial EMT in basal-like breast cancer cells, promoting collective invasion while maintaining cell cohesion.
bioRxiv · Apr 4, 2025 · PreprintCell Biology