Martijn Gloerich

Mechanical memory of confinement pressure governs expansion size in epithelial monolayers

The paper shows epithelial monolayers converge to the same final size and density after release from confinement, regardless of initial conditions, through mechanical pressure signaling.

Mechanical strain of the intestinal epithelium directs absorptive lineage maturation

This study shows that mechanical strain on intestinal organoids reduces the maturity of absorptive lineage cells by expanding early-stage enterocytes and downregulating maturation programs.

β-Catenin condensation facilitates clustering of the cadherin/catenin complex and formation of nascent cell-cell junctions

This study shows that β-catenin condensation drives the clustering of the cadherin/catenin complex and the formation of new cell-cell junctions.

Self-organization of tumor heterogeneity and plasticity

This study shows cancer cells follow intrinsic self-organized programs that coordinate tumor cell state transitions during growth, revealing mechanical gradients and stereotyped patterns of heterogeneity and plasticity.

Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia

The paper identifies sequential transcriptomic states of tuft cells along the intestinal crypt-villus axis and shows cytokine-specific differentiation into distinct tuft cell phenotypes.

Mechanical Coordination of Intestinal Cell Extrusion by Supracellular 3D Force Patterns

The paper investigates the mechanical mechanisms of intestinal cell extrusion, showing that it is driven by calcium-triggered myosin 2A mesh dissolution and lamellipodial forces, with extrusion direction determined by these structures.

Integrin-TGFb axis induces partial EMT in basal-like cells to lead collective invasion

The paper identifies the Itg2-TGFβ axis as a regulator of partial EMT in basal-like breast cancer cells, promoting collective invasion while maintaining cell cohesion.

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial cells by inducing ADAM-mediated ligand shedding

This study shows mechanical strain activates EGFR-ERK signaling in epithelial cells via E-cadherin-induced ADAM17-mediated ligand shedding.

PIEZO-dependent mechano-sensing of the niche is essential for intestinal stem cell fate decision and maintenance

This study shows PIEZO channels are essential for intestinal stem cell maintenance by sensing mechanical cues from their niche.