Monique M. A. Verstegen

This study evaluates drug responses in a patient-derived HCC chip model, showing varying effects on tumor cells and microenvironment factors like vasculature and cytokines.

This study shows that collagen scar formation during bile duct regeneration alters biomechanical properties, activating integrin-SRC/FAK signaling to drive ductular regeneration through a leading-tip of integrin-2-high cells.

The paper identifies the Itg2-TGFβ axis as a regulator of partial EMT in basal-like breast cancer cells, promoting collective invasion while maintaining cell cohesion.

This study develops hepatocyte-like liver organoids (HeLLOs) that closely mimic mature hepatocyte functions and outperform existing models in drug toxicity testing and disease modeling.

The paper identifies gene regulatory differences between primary human hepatocytes and organoid-derived hepatocytes using integrative omics analysis.

This paper demonstrates the use of prime editing to correct genetic mutations in patient-derived organoids, showing high efficiency and precision with minimal off-target effects.