AMP-activated-kinase (AMPK) is essential sensor and metabolic regulator of retinal neurons and their integrated metabolism with RPE.
Lei Xu, Emily E. Brown, Casey J. Keuthan, Himani Gubbi, Élodie-Kim Grellier, Jérôme E. Roger, Anand Swaroop, Jianhai Du, John D. Ash
This study shows that AMPK regulates retinal metabolism and that its loss leads to photoreceptor and RPE cell degeneration.
bioRxiv · May 22, 2020 · PreprintNeuroscience