Casey J. Keuthan

The paper identifies a compact Pol II promoter and hybrid Pol II/III promoters to enable efficient single-AAV delivery of SpCas9 for genome editing in human retinal ganglion cells.

The paper uses long-read RNA sequencing to study dynamic mRNA isoform changes during human retinal organoid development, revealing splicing patterns and allelic imbalance.

The paper examines regional gene expression differences in the retina, optic nerve head, and optic nerve of mice with glaucoma and optic nerve crush using bulk RNA-sequencing.

This study examines AQP4 expression in mouse optic nerve astrocytes under IOP elevation, finding no protective or detrimental effect of AQP4 absence on axon loss.

This study identifies gene regulatory networks controlling proliferative and neurogenic competence in retinal Muller glia.

This study shows that AMPK regulates retinal metabolism and that its loss leads to photoreceptor and RPE cell degeneration.