Functional Impact of Glycosylation and Splicing Variants of LRIG1 on EGFR Proteostasis in Cancer
Jumpei Kondo, Himari Nagao, Koki Oyama, Daisuke Sakon, Honoka Nakayama, Shinji Takamatsu, Eiji Miyoshi
The paper investigates how glycosylation and splicing variants of LRIG1 affect EGFR proteostasis in cancer, finding that N74Q mutation and exon 2 skipping enhance LRIG1-EGFR binding and degradation.
bioRxiv · Feb 5, 2025 · PreprintBiochemistry