Tcf21 as a Founder Transcription Factor in Specifying Foxd1 Cells to the Juxtaglomerular Cell Lineage
Hina Anjum, Jason P. Smith, Alexandre G. Martini, George Yacu, Silvia Medrano, R. Ariel Gómez, Maria Luisa S. Sequeira-Lόpez, Susan E. Quaggin, Gal Finer
This study identifies Tcf21 as essential for Foxd1+ progenitor cells to differentiate into juxtaglomerular cells during kidney development, showing reduced renin expression and altered renal morphology when Tcf21 is inactivated.
American Journal of Physiology-Renal Physiology · Dec 20, 2024Peer-reviewedDevelopmental Biology