Alexandre G. Martini

This study identifies renin-lineage cell fate reprogramming and metabolic dysfunction as drivers of concentric arterial hypertrophy, with potential biomarkers for early detection.

The paper maps interactions between renin cells and nerve fibers during kidney development and disease using single-cell RNA-Seq and imaging.

This study identifies Tcf21 as essential for Foxd1+ progenitor cells to differentiate into juxtaglomerular cells during kidney development, showing reduced renin expression and altered renal morphology when Tcf21 is inactivated.

The paper uses single-cell epi-transcriptomics to map the developmental trajectory of renin cell differentiation and identifies key transcription factors involved in their formation.