Silvia Medrano

Inhibition of Renin Release, a Crucial Event in Homeostasis, is Mediated by Coordinated Calcium Oscillations within Juxtaglomerular Cell Clusters.

This study investigates how AngII inhibits renin release in JG cell clusters through coordinated calcium oscillations, identifying key cellular mechanisms involved.

Hypoxia-Induced Metabolic Reprogramming and Markings of Cell Fate in Concentric Arterial Hypertrophy

This study identifies renin-lineage cell fate reprogramming and metabolic dysfunction as drivers of concentric arterial hypertrophy, with potential biomarkers for early detection.

Renin Cells Drive Kidney Neurovascular Development and Arterial Remodeling when Renin Activity is Deficient

The paper maps interactions between renin cells and nerve fibers during kidney development and disease using single-cell RNA-Seq and imaging.

Bright Cells, and Inefficient Enzymatic Activity in a Renin Hypomorph Mouse

This paper describes a mouse model with a bright fluorescent reporter for renin-expressing cells, revealing renin hypomorphism and associated kidney dysfunction under RAS inhibition.

Tcf21 as a Founder Transcription Factor in Specifying Foxd1 Cells to the Juxtaglomerular Cell Lineage

This study identifies Tcf21 as essential for Foxd1+ progenitor cells to differentiate into juxtaglomerular cells during kidney development, showing reduced renin expression and altered renal morphology when Tcf21 is inactivated.

An efficient inducible model for the control of gene expression in renin cells

This paper develops an inducible mouse model to specifically control gene expression in renin cells, demonstrating efficient and targeted deletion of renin in adult mice without developmental effects.

Protein Kinase A Inhibition Epigenetically Silences Ren1

The paper investigates how PKA inhibition affects renin expression by altering epigenetic marks and gene regulation at the renin locus.

Determinants of renin cell differentiation: a single cell epi-transcriptomics approach

The paper uses single-cell epi-transcriptomics to map the developmental trajectory of renin cell differentiation and identifies key transcription factors involved in their formation.