Gal Finer

This study uses scRNA-seq to show that Tcf21 is essential for Foxd1+ stromal progenitor differentiation during kidney development, with loss of Tcf21 causing stromal subpopulation depletion and emergence of Emcn-expressing cells.

This study identifies Tcf21 as essential for Foxd1+ progenitor cells to differentiate into juxtaglomerular cells during kidney development, showing reduced renin expression and altered renal morphology when Tcf21 is inactivated.

The paper identifies non-endothelial EMCN-expressing fibroblasts and pericytes in the choroid of mice and humans, showing they are distinct from endothelial cells and have unique gene expression profiles.