Cancer BiologyStem Cell ReportsPeer-reviewed
Impaired DNA damage response and inflammatory signalling underpins hematopoietic stem cell defects in Gata2 haploinsufficiency
Ali Abdelfattah, Ahmad Habib, Leigh-anne Thomas…·Neil P. Rodrigues
This study identifies how Gata2 haploinsufficiency disrupts HSC function and drives pre-leukemic changes through DNA damage and inflammatory signaling, with ASXL1 mutations exacerbating these defects.
4 citations