Author

Neil P. Rodrigues

Cardiff UniversityORCID 0000-0002-1925-7733Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Ahmad Habib· 1 shared Aisling S. Morrin· 1 shared Alex GibbsiD· 1 shared Alex TonksiD· 1 shared Alhomidi AlmotiriiD· 1 shared Ali AbdelfattahiD· 1 shared Ali Alshahrani· 1 shared Alice Cato· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Ahmad Habib

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Impaired DNA damage response and inflammatory signalling underpins hematopoietic stem cell defects in Gata2 haploinsufficiency

Ali Abdelfattah, Ahmad Habib, Leigh-anne Thomas, Juan Bautista Menendez-Gonzalez, Alhomidi Almotiri, Hind Alqahtani, Hannah Lawson, Sarab Taha, Millie Steadman, Radhika Athalye, Alex Gibbs, Hamed Alzahrani, Ali Alshahrani, Alice Cato, Peter J. Giles, , Neil P. Rodrigues

This study identifies how Gata2 haploinsufficiency disrupts HSC function and drives pre-leukemic changes through DNA damage and inflammatory signaling, with ASXL1 mutations exacerbating these defects.

Stem Cell Reports · Jul 31, 2025Peer-reviewedCancer Biology

IL-6 and IL-27 negatively regulate CRTAM-expressing CD4+ T-cells associated with lymphoid-driven synovitis.

Alicia Derrac Soria, Myles Lewis, Xiao Liu, Jason P. Twohig, Federica Monaco, Sandra Dimonte, Ana Cardus Figueras, Aisling S. Morrin, Carol Guy, Benjamin C. Cossins, Robert A. Benson, Robert Andrews, Barbara Szomolay, Ernest H Choy, Paul Garside, , Simon A. Jones

The paper identifies CRTAM-expressing CD4+ T-cells in lymphoid-driven synovitis and shows that IL-6 and IL-27 inhibit their activation through STAT3 and ZEB1.

bioRxiv · Sep 3, 2024 · PreprintImmunology