Senolytic targeting of CAF-induced KRT17+ colon cancer cells inhibits metastatic invasion
Daisuke Shiokawa, Hiroaki Sakai, Yusuke Kanda, Hirokazu Ohata, Yusuke Asada, Hiroki Ochiai, Takeo Fukagawa, Shigeki Sekine, Yasushi Yatabe, Masato Morikawa, Hitoshi Nakagama, Koji Okamoto
This study identifies KRT17+ colon cancer cells driven by TGF-β1 from CAFs that promote metastasis and shows that targeting these cells with senolytics reduces invasion and metastasis in xenograft models.
bioRxiv · Mar 5, 2026 · PreprintCancer Biology