Daisuke Shiokawa

This study identifies CTHRC1 as a protective factor in valvular interstitium that limits macrophage-driven calcification in aortic valve disease.

This study uses spatial transcriptomics to identify distinct molecular patterns in PPP and DE, revealing differences in AQP3 expression and STAT3 activation.

This study identifies KRT17+ colon cancer cells driven by TGF-β1 from CAFs that promote metastasis and shows that targeting these cells with senolytics reduces invasion and metastasis in xenograft models.

This study uses single-cell DNA and RNA sequencing to analyze intra-tumor heterogeneity dynamics in a mouse colorectal cancer model, finding increased RNA heterogeneity and decreased DNA heterogeneity after transplantation.