Koji Okamoto

The paper identifies CXCL16 macrophages in bone metastases that transiently restrain cancer growth and G-CSF niches that promote reactivation, revealing CAF-bone-marrow interactions as a therapeutic target.

This study identifies MTHFD1L as a critical regulator of breast cancer stemness and metastasis, showing its role in metabolic rewiring and tumor progression.

This study identifies KRT17+ colon cancer cells driven by TGF-β1 from CAFs that promote metastasis and shows that targeting these cells with senolytics reduces invasion and metastasis in xenograft models.

This study uses single-cell DNA and RNA sequencing to analyze intra-tumor heterogeneity dynamics in a mouse colorectal cancer model, finding increased RNA heterogeneity and decreased DNA heterogeneity after transplantation.