Epithelial Glutamate Retention Protects against Colitis
Hideya Iwaki, Yunosuke Yasuda, Nobufumi Kato, Hiroshi Kitamura, Hidehiro Hayashi, Shohei Murakami, Hideyo Sato, 魏范研, Shinji Fukuda, Tomoyoshi Soga, Takashi Kamei, Yoichi Kakuta, Atsushi Masamune, Hiroki Sekine, Hozumi Motohashi
This study identifies xCT upregulation in IBD as a disease-exacerbating factor and shows that inhibiting xCT or glutamine synthetase can protect against colitis.
bioRxiv · Apr 21, 2026 · PreprintMolecular Biology