Hozumi Motohashi

Epithelial Glutamate Retention Protects against Colitis

This study identifies xCT upregulation in IBD as a disease-exacerbating factor and shows that inhibiting xCT or glutamine synthetase can protect against colitis.

Sulfide:quinone oxidoreductase drives mitochondrial supersulfide metabolism to regulate bioenergetics and longevity in eukaryotes

This study shows that SQR is essential for mitochondrial function and longevity by regulating sulfur respiration and supersulfide metabolism in yeast and mice.

Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythroid Progenitors

The paper shows that mitochondrial content influences lineage commitment in megakaryocyte-erythroid progenitors, with mitochondria-rich cells favoring erythroid differentiation and mitochondria-poor cells favoring megakaryocyte differentiation.

Regnase-1 Promotes Tumor-Initiating Activity in Non-Small Cell Lung Cancer

This study shows Regnase-1 promotes tumor-initiating activity in NSCLC by suppressing the SOX2 pathway, and its inhibition reduces tumor growth and enhances anti-cancer immunity.

Glutathione supersulphide regulates T-cell receptor signalling

This study shows that glutathione supersulphide regulates T-cell receptor signalling by interacting with the CD3ε chain, affecting TCR activation and inflammation.