Author

Hiroki Sekine

Tohoku UniversityORCID 0000-0002-0929-6456Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Hozumi MotohashiiD· 2 shared Shohei MurakamiiD· 2 shared Atsushi MasamuneiD· 1 shared Haruna TakedaiD· 1 shared Hidehiro HayashiiD· 1 shared Hideya Iwaki· 1 shared Hideyo SatoiD· 1 shared Hiroshi Kitamura· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

Hozumi MotohashiORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintApr 21, 2026

Epithelial Glutamate Retention Protects against Colitis

Hideya Iwaki, Yunosuke Yasuda, Nobufumi Kato…·Hozumi Motohashi

This study identifies xCT upregulation in IBD as a disease-exacerbating factor and shows that inhibiting xCT or glutamine synthetase can protect against colitis.

DOI 10.64898/2026.04.18.718419

mouseexperimental assay

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Cancer BiologybioRxivPreprintJul 8, 2025

Regnase-1 Promotes Tumor-Initiating Activity in Non-Small Cell Lung Cancer

Keito Okazaki, Madoka Kawaguchi, Shohei Murakami…·Hozumi Motohashi

This study shows Regnase-1 promotes tumor-initiating activity in NSCLC by suppressing the SOX2 pathway, and its inhibition reduces tumor growth and enhances anti-cancer immunity.

DOI 10.1101/2025.07.08.663650

humanbulk RNA-seq

𝕏 PostBluesky