Tomoyoshi Soga

Renal nutrient loss promotes metabolic health at the expense of increased vulnerability to acute kidney injury

This study identifies a renometabolic trade-off where increased urinary nutrient loss protects against obesity but increases vulnerability to acute kidney injury.

The Gibbs free energy landscape based on liver metabolome revealed thermodynamic robustness against fasting and obesity

The paper maps the Gibbs free energy landscape of liver metabolism in mice during fasting and obesity, revealing thermodynamic robustness despite metabolic changes.

Mitochondrial one-carbon enzyme MTHFD1L sustains stemness and metastatic progression in breast cancer

This study identifies MTHFD1L as a critical regulator of breast cancer stemness and metastasis, showing its role in metabolic rewiring and tumor progression.

Folate-dependent one-carbon metabolism controls meiotic and post-meiotic epigenome remodeling in the male germline

This study shows folate deficiency during spermatogenesis causes stage-specific metabolic and chromatin changes in the male germline, affecting histone modifications and epigenetic inheritance.

Epithelial Glutamate Retention Protects against Colitis

This study identifies xCT upregulation in IBD as a disease-exacerbating factor and shows that inhibiting xCT or glutamine synthetase can protect against colitis.

Co-targeting an AMPK--MAPK axis reprograms CAFs and suppresses PDAC

This study shows that targeting the AMPK-MAPK axis in cancer-associated fibroblasts suppresses PDAC growth in fly and mouse models by restoring AMPK activity and inhibiting fibroblast activation.

Global loss of responsiveness in key regulator metabolites and elevated enzyme proteins as metabolic dysregulation in skeletal muscle and liver of obese mice during starvation

The paper examines metabolic adaptations during starvation in obese mice, finding impaired responsiveness and elevated enzyme expression in skeletal muscle and liver.

Identifying simultaneous inhibition of riboflavin metabolism and MEK as a novel therapeutic strategy for pancreatic cancer

The paper identifies dual targeting of riboflavin metabolism and MEK as a novel therapeutic strategy for pancreatic cancer by showing synergistic suppression of PDAC xenograft growth.

Structural robustness and temporal vulnerability of the starvation-responsive metabolic network in liver of healthy and obese mice

The paper examines how obesity disrupts the temporally ordered metabolic network in the liver during starvation, revealing structural robustness but temporal vulnerability.

Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity

The paper compares metabolic dysregulation in obese mice during feeding and fasting using multi-omics data, revealing opposite metabolic shifts linked to obesity.

In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states

This study uses multiomic analysis of skeletal muscle in obese and healthy mice to reveal differences in metabolic regulation by metabolites and genes after glucose administration.

Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism

This paper introduces OMELET, a method to infer metabolic flux from multi-omic data, and applies it to identify obesity-associated dysregulation in liver glucose metabolism.

Trans-omic analysis reveals allosteric and gene regulation-axes for altered glucose-responsive liver metabolism associated with obesity

The paper analyzes trans-omic data from healthy and obese mice to reveal that glucose-responsive liver metabolism is regulated by rapid changes in metabolites and gene expression in the healthy state, and by slow transcriptional regulation in the obese state.

Trans-omic analysis reveals fed and fasting insulin signal across phosphoproteome, transcriptome, and metabolome

The paper constructs a trans-omic network of insulin action using phosphoproteomic, transcriptomic, and metabolomic data to identify fed and fasting insulin signals.