PIKFYVE inhibition induces endosome- and lysosome-derived vacuole enlargement via ammonium accumulation
Junsuke Uwada, Hitomi Nakazawa, Takeshi Kiyoi, Takashi Yazawa, Ikunobu Muramatsu, Takayoshi Masuoka
This study shows that PIKFYVE inhibition causes endosome and lysosome enlargement through ammonium accumulation from glutamine metabolism, impairing lysosomal function and autophagic flux.
bioRxiv · Apr 19, 2024Cell Biology