Author

Hiu Nam Chan

University College London

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Developmental Biology· 1

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Approach:experimental assay· 1 Organism:mouse· 1

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Andrew J. CoppiD· 1 shared Dawn Savery· 1 shared Nina Wenzlitschke· 1 shared Pedro P. RochaiD· 1 shared Shreeta ChakrabortyiD· 1 shared

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Andrew J. CoppORCID

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1 paper

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Developmental BiologybioRxivPreprintNov 10, 2025

Absence of posterior commissure and sub-commissural organ precedes encephalocele development in a new mouse model

Hiu Nam Chan, Dawn Savery, Shreeta Chakraborty…·Andrew J. Copp

This study develops a new mouse model of encephalocele by over-expressing FGF3, 4, and 15, revealing the absence of posterior commissure and sub-commissural organ as a key developmental defect.

DOI 10.1101/2025.11.10.687701

mouseexperimental assay

𝕏 PostBluesky