Shreeta Chakraborty

This study develops a new mouse model of encephalocele by over-expressing FGF3, 4, and 15, revealing the absence of posterior commissure and sub-commissural organ as a key developmental defect.

The paper shows that disrupting chromatin domain boundaries with multiple developmental regulators can cause severe gene dysregulation and developmental defects in mice.

This study shows that MLL3/MLL4 methyltransferase activities are essential for early embryonic development and stem cell differentiation, but their role is lineage-selective and not dependent on enhancer activation.

The paper shows that high affinity enhancer-promoter interactions can bypass CTCF/cohesin insulation and maintain gene expression in some tissues but not others.