Dawn Savery

Chiari II brain malformation is secondary to open spina bifida

The paper demonstrates that Chiari II brain malformation arises secondary to open spina bifida in mice, showing structural brain and skull defects linked to neurogenesis and neuronal migration disturbances.

Absence of posterior commissure and sub-commissural organ precedes encephalocele development in a new mouse model

This study develops a new mouse model of encephalocele by over-expressing FGF3, 4, and 15, revealing the absence of posterior commissure and sub-commissural organ as a key developmental defect.

Severe neural tube defects due to failure of closure initiation can arise without abnormality of neuroepithelial convergent extension

The paper shows that severe neural tube defects can occur without abnormal convergent extension by linking GAG sulfation and partial PCP gene loss.

Novel mouse model of encephalocele: post-neurulation origin and relationship to open neural tube defects

This paper introduces a novel mouse model of encephalocele showing it arises post-neurulation and can share genetic causes with anencephaly.

Genetic approaches in mice demonstrate that neuro-mesodermal progenitors express T/Brachyury but not Sox2

The paper shows that neuro-mesodermal progenitors in mice express T/Brachyury but not Sox2, challenging the hypothesis that they co-express both markers.