Nodamuravirus protein B2 boosts self-amplifying mRNA efficacy by overcoming innate immune barriers.
Raul Y. Sanchez-David, Hoang Duy Le, Josephine Nemegeer, Amanda Costa Gonçalves, Andres Merits, Pierre V. Maillard
This paper shows that the Nodamura virus B2 protein enhances self-amplifying mRNA efficacy by suppressing innate immune responses in different cell types without affecting interferon signaling.
bioRxiv · Jun 27, 2025 · PreprintImmunology