Andres Merits

This study identifies EIDD-3525 as a broad-spectrum antiviral against alphaviruses that inhibits RNA replication by targeting the nsP4 polymerase.

The paper uses a pro-apoptotic CRISPR screening strategy in mosquito cells to identify Lachesin as a critical CHIKV entry factor.

This paper presents a cryo-EM structure of the Chikungunya virus replication complex, revealing two distinct RNA-binding sites involved in genome import and replication elongation.

This study identifies novel small-molecule inhibitors of Chikungunya virus replication through high-throughput screening and characterizes their mechanism of action and resistance profiles.

This study shows that dengue virus NS1 partially translocates to the nucleus, modulating host transcription and supporting viral replication.

This study investigates how structural proteins of TBEV influence viral tropism by comparing a chimeric virus with low-pathogenic LGTV and TBEV using structural and imaging analyses.

This paper shows that the Nodamura virus B2 protein enhances self-amplifying mRNA efficacy by suppressing innate immune responses in different cell types without affecting interferon signaling.

The paper shows that SARS-CoV-2 resistance to broadly neutralizing antibodies is due to altered spike conformational dynamics, not epitope mutations.

The paper validates infectious clones of flaviviruses with fluorescent markers to enable antiviral drug screening and replication studies.

The paper reports crystal structures of alphavirus nsP4 RNA polymerase domains and identifies dynamic regions critical for RNA replication.

This study maps SARS-CoV-2 RNA interactions in vivo, identifying structural elements and host RNA interactions that may contribute to viral pathogenicity.