Human MutLa activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity
Mohamed E. Ashour, Ellie Krekeler, Monika Chandan Bhowmik, Holland Kantar, Ning Tsao, Carlos Herrera-Montávez, Miaw-Sheue Tsai, Manal S. Zaher, Lyudmila Y. Kadyrova, Farid A. Kadyrov, Roberto Galletto, Nima Mosammaparast
The paper shows that MutL activates MPG to generate alkylation damage, contributing to cytotoxicity in MMS treatment.
bioRxiv · Dec 17, 2025Biochemistry