Author

Manal S. Zaher

Washington University in St. LouisORCID 0000-0002-7785-4384Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Roberto GallettoiD· 2 shared Alex Wu· 1 shared André NussenzweigiD· 1 shared Archana KrishnamoorthyiD· 1 shared Ayush MistryiD· 1 shared Carlos Herrera-MontáveziD· 1 shared Carrie M. W. Stith· 1 shared David S. PellmaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

Roberto GallettoORCID

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3 papers

Recent·Most cited

A CDK1 phospho-switch reprograms TRAIP to unload replisomes in mitosis

Geylani Can, Maksym Shyian, Archana Krishnamoorthy, Samreen Ahmed, Yang Lim, Alex Wu, Raphael Pavani, Manal S. Zaher, André Nussenzweig, Markus Räschle, Thomas E. Wilson, Thomas W. Glover, Johannes C. Walter, David S. Pellman

The paper identifies a phospho-switch mechanism that reprograms TRAIP to ubiquitylate replisomes in mitosis, enabling disassembly of unreplicated DNA.

Science · Jul 2, 2026Peer-reviewedBiochemistry

Dissecting the role of PCNA and Pif1 in replication of individual DNA molecules by DNA polymerase δ.

Manal S. Zaher, Carrie M. W. Stith, Ayush Mistry, Purna Bahadur Poudel, Edwin Antony, Peter Burgers, Roberto Galletto

This study uses single-molecule techniques to show PCNA, Pol δ, and Pif1 collaborate in DNA replication, with PCNA stabilization and diffusion reduction by both Pol δ and Pif1.

bioRxiv · May 21, 2026 · PreprintBiochemistry

Human MutLa activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity

Mohamed E. Ashour, Ellie Krekeler, Monika Chandan Bhowmik, Holland Kantar, Ning Tsao, Carlos Herrera-Montávez, Miaw-Sheue Tsai, Manal S. Zaher, Lyudmila Y. Kadyrova, Farid A. Kadyrov, Roberto Galletto, Nima Mosammaparast

The paper shows that MutL activates MPG to generate alkylation damage, contributing to cytotoxicity in MMS treatment.

bioRxiv · Dec 17, 2025Biochemistry