Nima Mosammaparast

The paper identifies RNF216 and OTUD4 as regulators of protein synthesis and degradation, showing their interaction disrupts neurodegeneration in Gordon Holmes syndrome.

This study identifies KDM7B as a demethylase that regulates RNF113A, affecting DNA repair and chemoresistance in small cell lung cancer.

The paper shows that MutL activates MPG to generate alkylation damage, contributing to cytotoxicity in MMS treatment.

The paper identifies COPS5 as a therapeutic target for overcoming platinum resistance in ovarian cancer by inhibiting nucleotide excision repair and interstrand crosslink repair.

This study shows that RNA damage can cause DNA breaks through R-loop formation, and YTHDC1-THOC prevents this by binding to m1A-modified RNAs.

This study shows the yeast Shu complex prevents mutagenesis from 3meC lesions by binding to them and reducing replication errors.

The paper shows RNA alkylation triggers recruitment of the ASCC repair complex via RNF113A, revealing RNA damage as a signal for DNA repair.