Systematic Dissection of Sequence Features Affecting the Binding Specificity of a Pioneer Factor Reveals Binding Synergy Between FOXA1 and AP-1
Cheng Xu, Holly Kleinschmidt, Jianyu Yang, Erik M. Leith, Jenna K. Johnson, Song Tan, Shaun Mahony, Lu Bai
The paper uses ChIP-ISO to analyze sequence features affecting FOXA1 binding and finds that AP-1 influences FOXA1 binding specificity and context-dependent binding.
Molecular Cell · Jul 16, 2024Peer-reviewedGenetics