Author

Erik M. Leith

Pennsylvania State UniversityORCID 0000-0003-2883-7753Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Song TaniD· 2 shared B.P. Manzano· 1 shared Cheng XuiD· 1 shared Cheng‐Ming ChiangiD· 1 shared Erin N. O’Donnell· 1 shared Holly Kleinschmidt· 1 shared Jean‐Paul ArmacheiD· 1 shared Jenna K. Johnson· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Song TanORCID

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2 papers

Recent·Most cited

Molecular BiologyMolecular CellPeer-reviewedAug 1, 2026

BRD4 binds the nucleosome via both histone and DNA interactions

Jiang Zhu, Erik M. Leith, Erin N. O’Donnell…·Song Tan

This study reveals how BRD4 binds nucleosomes through both histone and DNA interactions, showing that acetylation of H4 influences the BRD4/nucleosome complex conformation.

2 citations

experimental assay

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GeneticsMolecular CellPeer-reviewedJul 16, 2024

Systematic Dissection of Sequence Features Affecting the Binding Specificity of a Pioneer Factor Reveals Binding Synergy Between FOXA1 and AP-1

Cheng Xu, Holly Kleinschmidt, Jianyu Yang…·Lu Bai

The paper uses ChIP-ISO to analyze sequence features affecting FOXA1 binding and finds that AP-1 influences FOXA1 binding specificity and context-dependent binding.

21 citations

humanChIP-seq

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