Song Tan

BRD4 binds the nucleosome via both histone and DNA interactions

This study reveals how BRD4 binds nucleosomes through both histone and DNA interactions, showing that acetylation of H4 influences the BRD4/nucleosome complex conformation.

Functional interplay between H2B ubiquitylation and H2A.Z deposition

This study shows that H2B ubiquitylation inhibits H2A.Z deposition by SWR1C and is required for H2A.Z re-localization during replication stress.

Roles of histone chaperone Nap1 and histone acetylation in regulating phase-separation of chromatin arrays

This study investigates how histone chaperone Nap1 and acetylation of histone H3/H4 tails regulate phase-separation of chromatin arrays through dynamic DNA-histone interactions.

Systematic Dissection of Sequence Features Affecting the Binding Specificity of a Pioneer Factor Reveals Binding Synergy Between FOXA1 and AP-1

The paper uses ChIP-ISO to analyze sequence features affecting FOXA1 binding and finds that AP-1 influences FOXA1 binding specificity and context-dependent binding.