Uptake of CD36 and its natural and therapeutic ligands by clathrin-mediated endocytosis
Hao-Yang Liu, Zhengyu Wang, Rahul Sharma, Jessica Perez, Brandon Kusaj, Hongfei Zhou, Minmin Wang, Jon M. Huibregtse, Hong-Yu Li, Jeanne C. Stachowiak
This study shows CD36 and its ligands are internalized via clathrin-mediated endocytosis, not caveolae, and disrupting clathrin inhibits ligand uptake and PROTAC-induced degradation.
bioRxiv · Oct 24, 2026 · PreprintCell Biology