Derrick W Crook

Nanopore metagenomic sequencing of full length human metapneumovirus (HMPV) within a unique sub-lineage

This study uses Nanopore metagenomic sequencing to directly sequence the full-length HMPV genome from a UK patient, identifying a unique genetic group and demonstrating the utility of Nanopore for clinical diagnosis.

MinION Nanopore Sequencing of Multiple Displacement Amplified Mycobacteria DNA Direct from Sputum

This study evaluates the effectiveness of multiple displacement amplification followed by MinION sequencing for detecting Mycobacteria DNA in sputum samples.

Klebsiella quasipneumonaiae provides a window into carbapenemase gene transfer, plasmid rearrangements and nosocomial acquisition from the hospital environment

The paper tracks K. quasipneumoniae's acquisition of carbapenemase plasmids and environmental persistence in a hospital setting over multiple years.

High rates of human faecal carriage of mcr-1-positive multi-drug resistant isolates emerge in China in association with successful plasmid families

The paper reports a significant increase in mcr-1-positive multi-drug resistant Enterobacteriaceae in human faecal samples in China, associated with diverse plasmid families and chromosomal integration.

Nested Russian Doll-like Genetic Mobility Drives Rapid Dissemination of the Carbapenem Resistance Gene blaKPC

This paper tracks the rapid spread of the blaKPC resistance gene in a hospital over five years, revealing nested genetic mobility mechanisms that enable dissemination across species and plasmids.

Evolutionary history of the global emergence of the Escherichia coli epidemic clone ST131

This study traces the evolutionary history of the ST131 E. coli lineage, showing its clonal expansion linked to antibiotic use and plasmid acquisition, with implications for antimicrobial resistance control.