An in situ generated CAR-M with IFNg and negative dominance Sirpa isoform augments hepatocellular carcinoma immunotherapy
Xiang Li, Jing Hu, Tian Zhang, Hongceng Li, Quanrong Lai, Tao Wang, Yuxin Liu, Lan Zhang, Yonglong Wei, Wei Shi, Panpan Zhang
This paper develops a novel CAR-M targeting GPC3 with IFN-gamma and SIRPECD to enhance anti-tumor activity in hepatocellular carcinoma.
Journal of Nanobiotechnology · May 26, 2026Peer-reviewedCancer Biology