Tian Zhang

CysLENS: Interpretable signatures of cysteine ligandability from enantiomeric chemoproteomics and protein language models

CysLENS identifies cysteine ligandability by integrating chemoproteomic data with protein language models to prioritize stereoselective interactions.

An in situ generated CAR-M with IFNg and negative dominance Sirpa isoform augments hepatocellular carcinoma immunotherapy

This paper develops a novel CAR-M targeting GPC3 with IFN-gamma and SIRPECD to enhance anti-tumor activity in hepatocellular carcinoma.

Evaluating splicing factor and kinase network crosstalk through global phosphoproteomics

The paper investigates crosstalk between splicing factors and kinase networks using phosphoproteomics and RNA-seq data, showing significant changes in phosphorylation and kinase activity upon splicing factor knockdown.

Pharmacological recruitment of a VTA glutamatergic arousal circuit by the natural product BN3 drives broad-spectrum emergence from general anesthesia

The paper identifies BN3 as a broad-spectrum agent that accelerates emergence from general anesthesia by targeting a VTA glutamatergic arousal circuit.

A K27-linked Ubiquitin Checkpoint Controls NOTCH Homeostasis

This study identifies UVRAG as a negative regulator of NOTCH1 by promoting K27-linked ubiquitination and lysosomal degradation, revealing a checkpoint to prevent excessive NOTCH signaling.

Impact of oral Chlamydia Vaccination on Host Gut Microbiome and Metabolites Composition

This study examines the effects of oral Chlamydia vaccination on gut microbiome and metabolite composition, identifying microbial and metabolic changes and potential biomarkers of immunization.

Chemical History Shapes the Antigenic Identity of MHC-I Epitopes

The paper shows that chemical modifications of MHC-I epitopes affect T cell recognition, demonstrating that antigenic identity depends on both sequence and chemical history.