Benchmarking Sequence-Based and AlphaFold-Based Methods for pMHC-II Binding Core Prediction: Distinct Strengths and Consensus Approaches
Soobon Ko, Honglan Li, Hongeun Kim, Woong‐Hee Shin, Junsu Ko, Yoonjoo Choi
This paper benchmarks sequence-based and AlphaFold-based methods for predicting pMHC-II binding cores, finding that AlphaFold-based methods excel at identifying binders while NetMHCIIpan is better at identifying non-binders.
BMC Medical Genomics · Jul 22, 2026Peer-reviewedBioinformatics