A female-specific CB1R-gated subcortical circuit orchestrates defensive homeostasis in risk assessment
Xue Liu, Hongren Huang, Xiaolong Feng, Xulin Li, Jialin Ye, Huan Min Yang, Jingjing Liu, Zicong Liang, Zhihan Guo, Ruyi Cai, Shangxuan Cai, Yulong Li, Zhaofa Wu, Liping Wang
The paper identifies a female-specific subcortical circuit involving CB1R that maintains defensive homeostasis during risk assessment by modulating GABA release in the lateral habenula.
bioRxiv · Sep 23, 2025 · PreprintNeuroscience