Yulong Li

Development of a genetically encoded fluorescent indicator for monitoring GPR52 activation

The paper develops a genetically encoded fluorescent sensor to monitor GPR52 activation, enabling detection of endogenous ligand release and real-time activation monitoring.

Nicotinic modulation of frontal circuits breaks the cycle of attentional performance failure

The paper identifies a cholinergic mechanism in frontal circuits that restores attentional performance after repeated errors in a mouse model.

Seizures in a Dravet Syndrome mouse model inhibit the locus coeruleus but locally evoke supraphysiologic norepinephrine release

The paper investigates NE release during seizures in a Dravet Syndrome mouse model, finding inhibited LC-NE neuron activity but increased NE release in downstream regions.

A general method to develop excitation ratiometric neuropeptide sensors with enhanced sensitivity for in vivo applications

The paper introduces a method to create excitation ratiometric neuropeptide sensors with improved sensitivity for in vivo use by using dual excitation and fluorescence correction.

Selective GRAB sensors reveal distinct endocannabinoid dynamics in vivo

The paper develops selective fluorescent sensors to detect endocannabinoid dynamics in vivo and shows that Δ9-THC induces sustained 2-AG signaling in the nucleus accumbens.

Simultaneous, real-time tracking of many neuromodulatory signals with Multiplexed Optical Recording of Sensors on a micro-Endoscope

This paper develops a micro-endoscope probe to simultaneously track multiple neuromodulators in real time using fluorescent sensors, demonstrating its use in brain slices and awake mice.

Adult Clock Neuron Somatic Neuropeptide Release and Cytonemes Regulate Sleep

The paper investigates how s-LNv clock neurons regulate sleep through neuropeptide release and cytoneme-mediated communication with l-LNv neurons.

Stimulus-Dependent Dopamine Dynamics from LocusCoeruleus Axons

This study identifies the physiological and behavioral conditions that trigger dopamine release from locus coeruleus axons, showing modality-dependent release constraints.

Paw switching with lateralized cholinergic modulation

This study shows that cholinergic modulation between brain hemispheres enables paw preference switching in mice through experience-driven changes in neural activity.

Coordinated acetylcholine release and adaptation of neuronal representations in the retrosplenial cortex during contextual uncertainty

The paper shows acetylcholine release in the retrosplenial cortex correlates with changes in expected uncertainty and influences neuronal representation shifts and learning speed in mice.

Peri-Locus Coeruleus Controls Endothelial Cell Heterogeneity in Enriched Environments via Region-Specific Norepinephrine Signaling

This study shows that peri-LC neurons regulate bone endothelial heterogeneity and density through norepinephrine signaling in enriched environments.

Red-shifted GRAB acetylcholine sensors for multiplex imaging in vivo

The paper develops red-shifted GRAB acetylcholine sensors for multiplex imaging of ACh and other neuromodulators in vivo with high spatiotemporal resolution.

A synaptic mechanism for encoding the learned value of action-derived safety

The paper identifies a thalamostriatal circuit mechanism by which internally constructed outcomes, like safety, acquire motivational value through synaptic plasticity in mice.

Inferring norepinephrine dynamics from partial observations reveals the temporal structure of elevations during arousal

The paper develops methods to infer norepinephrine dynamics from partial observations, revealing temporal patterns during arousal.

Distinct modes of dopamine modulation on striatopallidal synaptic transmission

This study investigates how dopamine modulates striatopallidal synapses in different GPe subregions, revealing region-specific presynaptic and postsynaptic inhibition mechanisms.

Neuropeptide Y co-opts neuronal ensembles for memory lability and stability

The paper identifies NPY+ interneurons in the ventral hippocampus that regulate memory extinction through distinct sub-ensembles via fast and slow inhibition.

A genetically encoded fluorescent sensor for monitoring spatiotemporal prostaglandin E2 dynamics in vivo

This paper develops a genetically encoded fluorescent sensor, GRABPGE2-1.0, to monitor spatiotemporal PGE2 dynamics in vivo with high resolution.

Cholinergic-dopaminergic synergy and antagonism shape prediction-error broadcasting

The paper investigates how cholinergic and dopaminergic pathways interact in reward prediction-error signaling through optogenetic and chemogenetic experiments in mice.

Oxytocin facilitates social behavior of female rats via selective modulation of interneurons in the medial prefrontal cortex

This study identifies a circuit in the medial prefrontal cortex where oxytocin modulates interneurons to promote social behavior in female rats, even under physiological stress.

Master clock-thalamic-prefrontal circuit controls circadian social priority

The paper identifies a circadian circuit linking the SCN to the mPFC that regulates social prioritization through Vipr2 signaling in the RE.

Coordinated infraslow cortical oscillations of neuromodulators during NREM sleep

The paper investigates coordinated infraslow cortical oscillations of multiple neuromodulators during NREM sleep in mice and finds they are regulated by specific neural circuits.

PKU tags, novel genetically encoded shape tags for cell labeling in light and electron microscopy

The paper introduces PKU tags, genetically encoded shape tags for cell labeling in light and electron microscopy, enabling multi-cell-type labeling and circuit tracing without altering behavior or transcriptomes.

A female-specific CB1R-gated subcortical circuit orchestrates defensive homeostasis in risk assessment

The paper identifies a female-specific subcortical circuit involving CB1R that maintains defensive homeostasis during risk assessment by modulating GABA release in the lateral habenula.

Serotonin shapes the temporal window for associative fear learning

This study shows serotonin modulates the time window for fear learning by regulating neuronal activity in the ventral hippocampus.

Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control

This study investigates how phase synchrony between prefrontal noradrenergic and cholinergic signals relates to inhibitory control in mice.

Concerted actions of distinct serotonin neurons orchestrate female pup care behavior

The paper identifies two distinct serotonin neuron populations that regulate pup care behavior in female mice, showing how they switch function across reproductive stages.

Molecular recording of cellular protein kinase activity with chemical labeling

The paper introduces molecular recorders to track kinase activity in cells and applies them to study PKA activity and neuromodulation.

Striatal dopamine reflects individual long-term learning trajectories

This study shows that dopamine signals in the striatum reflect long-term learning strategies in mice, with a deep neural network model capturing these dynamics through reinforcement learning.

Multiple-level organizational logic of the locus coeruleus-norepinephrine system in structure and function

The paper reveals how locus coeruleus-norepinephrine neurons organize to regulate brain-wide neural dynamics through region-specific axon projections and synchronized firing.

In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors

The paper introduces a far-red dopamine sensor, HaloDA1.0, enabling multiplex imaging of neurochemical networks in vivo with high sensitivity and versatility.